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Thursday’s Best NFL, College Football & MLB Bets (9/21)

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No matter your sport of choice, there's always sports betting action to be had. We'll have you covered each and every day with our daily best bets. Here are all of our best bets across each major sport in action today.

Today's Best Bets

Here are today's best bets.

NFL Best Bets

(Odds courtesy of DraftKings Sportsbook)

New York Giants @ San Francisco 49ers

This almost feels like a trap. If this would have opened at 14, it still would have been a play on the 49ers. So, why is the spread just 10 points between two teams that are so unevenly matched? 

Without an answer to that question, we're simply taking the much better team to dominate in a game they should have no trouble dominating. For six quarters, the Giants looked like the worst team in football. They mounted a nice comeback in Week 2, but they never should have been trailing the lowly Arizona Cardinals by 21 in the first place. 

The Giants have ruled out Saquon Barkley. Yet, with or without him, the 49ers' defense is too good for the Giants' offense, especially that terrible offensive line. This is a game that the 49ers should win by close to 20 points. 

Bet: San Fransisco 49ers -10.5 (-108)

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College Football Bets

(Odds courtesy of DraftKings Sportsbook)

NC State @ Virginia

NC State hasn't looked quite like we wanted them to yet, but I think this is the week they turn it on. Brennan Armstrong followed his OC Robert Anae from Virginia, and they will want to put up big numbers this week. The magic hasn't been there yet for Armstrong, who put up nearly 4,500 yards and 40 TDs (31 passing, nine rushing) in 2021 for the Cavaliers.

NC State isn't killing it on offense (61st in scoring, 31 PPG), but Virginia has been abysmal on defense. UVA is allowing 42.3 PPG so far, good enough to put them at 129th in the nation. Virginia allows 191 rushing yards per game (120th) and just over 260 yards passing (106th). By PFFs metrics, UVA is bottom five in overall defense, dead last in rushing and in the 80s in coverage. No matter how it's cut, Virginia is rough on defense.

UVA isn't saying which QB will start on Friday, but it's either starter Tony Muskett, at likely less than 100%, or Anthony Colandrea, who has been hit or miss. NC State is middling on defense, but UVA is almost as bad on offense as they are on defense, rating 108th in scoring (20.7 PPG), 128th in rushing (68 YPG) and 58th in passing (248.7 YPG). I'm threading the needle a bit here, but with NC State not hitting its stride, we can hit the spread and keep the under.

Bet: NC State -9.5 (-112) & UNDER 48 (-110)

Check out our other College Football Odds, Picks & Predictions

MLB Best Bets

(Odds courtesy of DraftKings Sportsbook)

Toronto Blue Jays @ New York Yankees

Gerrit Cole is continuing his stellar 2023 campaign, and over his last 14 starts, he's gone at least six innings and allowed two or fewer runs in 10 of them. It looks like he'll win the American League Cy Young race, but he and the Yankees are also looking to play spoilers to an American League East rival.

While Blue Jays starter Jose Berrios is having a much better 2023 than last year, he's still struggling with consistency this season. In August, he was an abysmal 1-3 with a 5.53 ERA in four starts. In September, he's 2-0 with a 1.80 ERA in three starts.

Even with the Yankees' offense being cold the last two games, they'll be able to do just enough to support Cole for the win.

Pick: Yankees Moneyline (-135)

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