Titans vs. Saints: NFL Week 1 Odds & Picks (2023)

Sunday marks the first full slate of NFL games for the 2023 season. Make sure to check in with BettingPros throughout the year for top picks and predictions for each and every NFL game. Our writers dive into their favorite picks and predictions for every remaining game on this weekend’s NFL slate. And let’s take a closer look at Titans vs. Saints.

Go premium to view top prop bets based on Cover Probability, Expected Value & Star Rating >>

NFL Week 1 Odds, Picks & Predictions: Titans vs. Saints

Titans vs. Saints

The Saints won't have Alvin Kamara available to begin the season. Keandre Miller is also questionable for this game. Therefore, Jamaal Williams will be the bell cow for the Saints, just like he was for the Lions. It worked out for the Lions and should be OK against the Titans. However, the Titans played solid defense against the run last year. That's something to consider in this game. The Saints weren't great at run-blocking, either. Conversely, the Titans were without Ryan Tannehill for much of last season. He's back in action and likely has a chip on his shoulder, knowing two quarterbacks were drafted in the last two seasons to take his spot potentially. The Titans will hand the ball off to Derrick Henry and have some success. But Tannehill's receivers are still a significant question mark, even with DeAndre Hopkins signed. I'll take the Saints at -3.

Pick: Saints -2.5 (-110)


What is Betting Against the Spread?

Betting "against the spread" refers to the act of choosing the winning team based on a numeric handicap placed on the team that oddsmakers believe is superior, rather than picking the outright winner. For example, if the Rams face the Bengals, and oddsmakers set the spread at Rams -3.5, you would need Los Angeles to win by 4 or more points in order to cash your Rams bet.

What is an Over/Under Bet?

Over/Under is a wager based on how many points you think will be scored in a specific game. Oddsmakers set the total, and bettors decide whether the final score will be higher or lower than that number. If an Over/Under is set at 44.5 points and you bet Over, you will need the combined score of both teams to be 45 points or higher to win your bet.

What is a Moneyline Bet?

A moneyline bet involves choosing which team you believe will win a specific matchup. The moneyline favorite carries a minus designation, like -130. This means that you need to wager $130 to earn a $100 profit. Conversely, the underdog carries a plus designation, like +110. This means that you win $110 in profit on a $100 bet.


Subscribe: Apple Podcasts | Spotify | Google Podcasts | Stitcher | RadioPublic | Breaker | Castbox | Pocket Casts

Whether you're new to sports betting or a betting pro, our Sports Betting Strategy and Advice page is for you. You can get started with our 101 section - including 10 Sports Betting Tips for Beginners - or head to more advanced strategy - like Key Numbers When Betting Against the Spread - to learn more.

Try Premium for FREE in our mobile app