Top MLB Betting Odds & Picks for Wednesday, April 27th (2022)

Tuesday was a great day for favorites, as they won 12 of the 15 games. For the season, favorites are now winning at a 61.9% clip (159-98) while unders are cashing at a 59.2% rate. Will those trends continue today?

Here are our best bets for Wednesday's MLB action. (Odds courtesy of DraftKings)

View the best player prop bets for tonight’s slate with our MLB Prop Bet Cheat Sheet >>

Los Angeles Dodgers vs. Arizona Diamondbacks O/U 

Just as we did on Monday when Walker Buehler became the first pitcher in baseball this season to throw a complete game shutout, we are backing the under in this Dodgers-Diamondbacks series finale. While Julio Urias’ stuff is not as intimidating as Buehler’s, he is still plenty effective. Since a rough first outing, Urias (1-1, 3.00) has pitched brilliantly, holding the Reds and Padres to one earned run on three hits in ten combined innings. He is opposed by Arizona’s Zac Gallen (0-0, 1.00), whose first two starts have come against the Mets. Gallen has pitched nine innings and allowed four hits while striking out nine thus far.

Both pitchers have been averaging at least one strikeout per inning over their last two starts, so trends suggest there will be fewer balls in play than usual. The under has cashed in each of Gallen’s last four Wednesday starts, and the under is 7-2-1 in Los Angeles’ ten games as road favorites this year. While the pitching matchup may not be the sexiest, these are still two of the more under-the-radar pitchers in the National League.

Bet: Dodgers-Diamondbacks UNDER 8 (-105 at DraftKings)  

Miami Marlins vs. Washington Nationals ML

Speaking of under-the-radar pitchers, Miami’s Pablo Lopez (2-0, 0.52) has had a sensational start to this season. However, the truth is Lopez has been dealing ever since the tail end of last season, and the Marlins are 6-0 in his previous six starts. Miami has a considerable pitching advantage in this matchup as they face Washington’s Erick Fedde (1-1, 6.75). Fedde has allowed a hard-hit percentage of 41.9%, which is on pace to be his worst in the last three seasons. In addition, his line drive percentage allowed is an astronomical 32.6%, and he is getting the fewest percentage of ground ball outs (39.5%) of his career by a wide margin so far. 

The Marlins are just 23-59 in their last 82 meetings against the Nationals in Washington, but the fact that they are sizeable road favorites in this contest speaks to how much of an advantage they have with Lopez toeing the rubber.

Bet: Miami Marlins ML (-140 at DraftKings)  

Cleveland Guardians vs. Los Angeles Angels RL

Most of us have been waiting for a vintage Shohei Ohtani performance on the mound, as he is 1-2 with a 4.40 ERA through his first three starts. However, that dominant performance should come against a Guardians team that has struggled offensively after a hot start. Cleveland still leads all AL Central teams with 76 runs scored, but they have totaled just eight runs during a five-game losing streak.

The Angels are 8-0 in Ohtani’s last eight home starts against teams with a losing record, and the under is 4-0 in Ohtani’s last four home starts. Thus, we are backing these trends in support of a lopsided Angels win tonight.

Bet: Los Angeles Angels -1.5 Runs (+110 at DraftKings)  

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Mike Spector is a featured writer at BettingPros. For more from Mike, check out his archive and follow him @MikeSpector01.